{"id":353,"date":"2022-02-21T23:30:37","date_gmt":"2022-02-21T14:30:37","guid":{"rendered":"https:\/\/www.bm-s.biz\/?post_type=news&p=353"},"modified":"2024-01-10T23:31:43","modified_gmt":"2024-01-10T14:31:43","slug":"a-joint-research-paper-about-pain-releif-by-msc-cultured-with-our-aof-medium-has-been-published-in-plos-one","status":"publish","type":"news","link":"https:\/\/www.bm-s.biz\/en\/news\/a-joint-research-paper-about-pain-releif-by-msc-cultured-with-our-aof-medium-has-been-published-in-plos-one\/","title":{"rendered":"A joint research paper about pain releif by MSC cultured with our AOF medium has been published in “PLOS ONE”."},"content":{"rendered":"

It has been published in “PLOS ONE” that mesenchymal stem cell (MSC) cultured with our AOF medium has therapeutic effect on neuropathic pain.
\nUsing a rat model of partial sciatic nerve ligation (PSNL) as a neuropathic pain model, we investigated the effects and mechanisms of intravenous administration of human adipose (AD) or umbilical cord (UC)-derived mesenchymal stem cells (MSC). As a result, in addition to reducing the pain response (von Fray test), it was demonstrated that the expression level of ATF-3 protein induced by PSNL in the dorsal root ganglion was significantly suppressed, suggesting that neuropathic pain was alleviated by MSC administration. Additionally, UC-MSC significantly ameliorated the PSNL-induced decrease in myelin basic protein levels in the sciatic nerve, implying that UC-MSC restores demyelination in the sciatic nerve. These data suggest that AD- and UC-MSC may be useful in the recovery of neuropathic pain.<\/p>\n

Miyano K. et al., Intravenous administration of human mesenchymal stem cells derived from adipose tissue and umbilical cord improves neuropathic pain via suppression of neuronal damage and anti-inflammatory actions in rats. PLoS One. 2022 Feb 14;17(2):e0262892.<\/p>\n","protected":false},"author":1,"featured_media":0,"template":"","news_category":[21],"acf":[],"yoast_head":"\nA joint research paper about pain releif by MSC cultured with our AOF medium has been published in "PLOS ONE". | \u30d0\u30a4\u30aa\u30df\u30e1\u30c6\u30a3\u30af\u30b9\u30b7\u30f3\u30d1\u30b7\u30fc\u30ba<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bm-s.biz\/en\/news\/a-joint-research-paper-about-pain-releif-by-msc-cultured-with-our-aof-medium-has-been-published-in-plos-one\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A joint research paper about pain releif by MSC cultured with our AOF medium has been published in "PLOS ONE". | \u30d0\u30a4\u30aa\u30df\u30e1\u30c6\u30a3\u30af\u30b9\u30b7\u30f3\u30d1\u30b7\u30fc\u30ba\" \/>\n<meta property=\"og:description\" content=\"It has been published in “PLOS ONE” that mesenchymal stem cell (MSC) cultured with our AOF medium has therapeutic effect on neuropathic pain. Using a rat model of partial sciatic nerve ligation (PSNL) as a neuropathic pain model, we investigated the effects and mechanisms of intravenous administration of human adipose (AD) or umbilical cord (UC)-derived mesenchymal stem cells (MSC). As a result, in addition to reducing the pain response (von Fray test), it was demonstrated that the expression level of ATF-3 protein induced by PSNL in the dorsal root ganglion was significantly suppressed, suggesting that neuropathic pain was alleviated by MSC administration. Additionally, UC-MSC significantly ameliorated the PSNL-induced decrease in […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.bm-s.biz\/en\/news\/a-joint-research-paper-about-pain-releif-by-msc-cultured-with-our-aof-medium-has-been-published-in-plos-one\/\" \/>\n<meta property=\"og:site_name\" content=\"\u30d0\u30a4\u30aa\u30df\u30e1\u30c6\u30a3\u30af\u30b9\u30b7\u30f3\u30d1\u30b7\u30fc\u30ba\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-10T14:31:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.bm-s.biz\/wp\/wp-content\/uploads\/2024\/01\/ogp.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" 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