optimized for each disease
Mesenchymal stem cells greatly vary in characteristics depending on culture conditions.
Therefore, optimization of the characteristics of mesenchymal stem cells to be used for treatment is important to yield high therapeutic effects in their respective target diseases. In addition, the same therapeutic effect achieved with fewer cells contributes to reductions in the treatment costs and improvement of safety.
These can be easily achieved by our AOF platform.
We call such a cell “Nao Cell®.”
Mesenchymal stem cells are expected to be beneficial in various diseases, such as cardiovascular diseases, autoimmune disorders, and fibrosis. Excellent therapeutic benefits have an impact on not only the original purpose of curing diseases but also on the reduction of medical costs, shortening of treatment duration, and satisfaction with treatment.
We have a library of supplements to prepare cells with enhanced functions in each disease area. In the future, we will work for transfection with genes or miRNA that can bring greater changes in the profile of mesenchymal stem cells.
MSCs characterized by potent immunosuppressive effect
An immunosuppressive effect is among the important functions of mesenchymal stem cells. Our cells have been confirmed to show a much more potent immunosuppressive effect than conventional serum media. Thus, the cells are expected to be highly effective in autoimmune disorders.
(Shown below: Study of the inhibition of growth of activated T cells)
MSCs characterized by an anticancer effect
Mesenchymal stem cells are reported to have both positive and negative effects on cancer. Mesenchymal stem cells prepared with our culture technology have been confirmed to exhibit a reproducible antitumor effect when transplanted in a mouse tumor-bearing model.
These findings indicate that safety is provided even in the presence of undetected cancer when MSCs are used for the treatment of any disease. In addition, although the mechanism of the anticancer effects of our MSCs is under study, it may be different from the mechanisms of existing anticancer agents. In such a case, MSCs may be used for cancer therapy in the future when their antitumor effect is further enhanced and is found to be synergistic with other cancer drugs.
Nao Cell® highly expressing certain functional factors
In addition, we have technologies for preparing multiple types of mesenchymal stem cells, including MSCs highly expressing VGEF, a factor playing an important role in ischemic disorders, and MSCs highly expressing neprilysin, an enzyme that degrades amyloid beta peptides, a causative agent of Alzheimer’s disease.
These cells have been achieved by controlling medium compositions. In the future, we will maximize the therapeutic effect of mesenchymal stem cells through transfection with miRNA or mRNA as master regulators in order to create more highly functional and immature mesenchymal stem cells.
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